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王健生  
研究领域(方向)

1.   乳腺良恶性疾病的防治;

2.   恶性肿瘤综合治疗和术后复发转移的预防。

专长:消化、呼吸系统恶性肿瘤和乳腺癌的诊断治疗。

个人及工作简历

毕业后一直从事肿瘤学研究,研究方向为肿瘤免疫治疗学基础和肿瘤生物信息学。2002年获医学博士学位,博士期间从事消化道肿瘤的生物信息学研究。2009—2010年在美国MD Anderson 癌症中心访问交流。

工作履历:

1989年-1996年 西安医科大学临床医疗系七年制专业学习,获肿瘤学硕士学位。

1996年-1998年 金沙2004路线js5医学院第一附属医院肿瘤外科,任住院医师,完成急诊科,肿瘤内科,肿瘤放疗科,影像中心,心脏外科等相关科室轮转。

1998年-1999年 金沙2004路线js5医学院第一附属医院肿瘤外科,任总住院医师。

1999年-2002年 金沙2004路线js5医学院临床医学外科学专业学习,获博士学位。

1999年-2005年 金沙2004路线js5医学院第一附属医院肿瘤外科,任主治医师。

2005年-2010年 金沙2004路线js5医学院第一附属医院肿瘤外科,任副教授。

2007年3月    入选“金沙2004路线js5青年骨干教授培养计划”。

2007年-2019年 金沙2004路线js5医学院第一附属医院学科建设办公室主任。

2010年-       金沙2004路线js5医学院第一附属医院肿瘤外科,任教授。

2018年-       韩城市人民医院,任院长。

科研项目

1.   国家自然科学基金 基于蛋白组学的胆囊癌FTIR医学模型的构建(30500119)

2.   国家自然科学基金 NPRA通过上调趋化因子CCL2促进胃癌EMT和侵袭转移的机制研究(81702430)

3.   国家自然科学基金 打靶表皮生长因子受体III型突变体的胞内抗体抗肿瘤研究(30600744)

4.   国家自然科学基金 口服型Ecn-Apoptin治疗消化道肿瘤的实验研究(81072053)

5.   国家自然科学基金 LPAR3促进三阴性乳腺癌ER、PR缺失及HER2低表达的分子机制及临床意义(81502295)

6.   陕西省科技攻关项目 口服分泌表达凋亡素的益生菌治疗消化道肿瘤的实验研究(2010K14-02)

7.   西安市科技攻关项目 乳腺疾病防治网络体系的推广应用研究(SF09025-(5))

8.   教育部博士点基金 转导Apoptin- CPP造血干细胞防治实体瘤术后复发转移的实验研究(20060698055)

9.   教育部新世纪人才支持计划 消化道肿瘤的转移预防(NCET-06-0838)

学术及科研成果、专利、论文

科技成果:

获省部级科研成果奖7项,其中陕西省科技进步奖一等奖一项(第二完成人),陕西省科技进步奖二等奖两项(第一及第三完成人),陕西省科技进步奖三等奖三项(分别为第一、第二、第三完成人)。

专利: 共申请国家发明专利5项

论文:近年来发表学术论文200余篇,其中SCI收录80余篇。

2006年入选教育部“新世纪优秀人才支持计划”,2006年荣获陕西省第六届青年科技奖和陕西省青年突击手称号,2015年获国家民政部“全国首批五星级志愿者”,2016年获第三届陕西省“雷锋式职工”标兵个人、陕西省“最美志愿者”荣誉称号, 2016荣获“健康中国年度十大人物”。2017、2018年获得“中国基层帮扶领袖人物”。 发起组建了陕西省抗癌协会乳腺疾病防治协作组,目前成员单位覆盖陕西省内94个县市,服务人口超过两千万,深受三秦百姓的欢迎。

学术兼职:

1.   陕西省抗癌协会副秘书长;

2.   中国医师协会科普分会委员;

3.   中华医学会科普分会青年委员;

4.   中国教育协会成人继续教育协会委员;

5.   陕西省性学会乳腺癌专业委员会主任委员;

6.   陕西省健康质量控制中心委员;

7.   陕西省抗癌协会临床协作专业委员会主任委员;

8.   陕西省抗癌协会乳腺癌专业委员会副主任委员;

9.   陕西省抗癌协会食管癌专业委员会常务委员;

10. 陕西省抗癌协会肺癌专业委员会常务委员;

11. 中华肝胆外科杂志通讯编委;

12. 中华消化外科杂志通讯编委;

13. 中华实验外科杂志特约编辑;

14. 中国现代普通外科进展杂志编委;

15. 世界华人消化杂志编委;

16. 金沙2004路线js5学报(社科版)编委;

17. 金沙2004路线js5学报(医学版)编委;

18. 现代肿瘤医学杂志中青年编委;

19. The Chinese Medical Journal (CMJ) 审稿专家;

20. 中华临床医师杂志(电子版)审稿专家;

21. 第四军医大学学报审稿专家;

22. 金沙2004路线js5学报(医学版)编委;

23. 中国组织工程研究与临床修复编委。

SCI收录文章:

1.   Wang J, Sun Y, Qu J, Zuo H, Zhao X, Liu L, Feng J, Wang J*, Zhang G*. Survival analysis for male ductal and lobular breast cancer patients with different stages[J]. Future Oncology, 2019 Jan.(SCI, IF= 2.12)[PMID:30088776]

2.   Wang J , Sun Y , Qu J , Zuo H , Zhao X , Liu L , Feng J , Wang J* , Zhang G* . Morphological analysis of blood vessels near lung tumors using 3-D quantitative CT[J]. Journal of X-ray science and technology.2018 Nov 8.(SCI, IF= 1.11)[PMID:30412516]

3.   Wang J , Liu L , Sun Y , Xue Y , Qu J , Pan S , Li H , Qu H , Wang J* , Zhang J* . miR-615-3p promotes proliferation and migration and inhibits apoptosis through its potential target CELF2 in gastric cancer[J]. Biomedicine & Pharmacotherapy, 2018 May.(SCI, IF= 2.32)[PMID:29501762]

4.   Qu J , Zhao X , Wang J , Liu X , Yan Y , Liu L , Cai H , Qu H , Lu N , Sun Y , Wang F , Wang J* , Zhang J*, MYC overexpression with its prognostic and clinicopathological significance in breast cancer, Oncotarget. 2017 Oct 5.(SCI, IF=  4.73)[PMID:29212204]

5.   Ya Yang#, Jia Zhang#, Yan Yan, Hui Cai, Min Li, Kai Sun, Jizhao Wang, Xu Liu, Jiansheng Wang*, Xiaoyi Duan*, Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer, Oncotarget. 2017 Jan 31 .(SCI, IF= 4.73)[PMID:28009991]

6.   Sun K, Duan X, Cai H, Liu X, Yang Y, Li M, Zhang X, Wang J.Curcumin inhibits LPA-induced invasion by attenuating RhoA/ROCK/MMPs pathway in MCF7 breast cancer cells.Clin Exp Med. 2016 Feb .(SCI, IF= 2.36)[PMID:25596714]

7.   Min Li#, Dong Xiao, Jia Zhang, Hangying Qu, Ya Yang, Yan Yan, Xu Liu, Jizhao Wang, Lin Liu, Jiansheng Wang*, Xiaoyi Duan*, Expression of LPA2 is associated with poor prognosis in human breast cancer and regulates HIF-1α expression and breast cancer cell growth, Oncol Rep, 2016 Dec. (SCI, IF= 2.73)[PMID:27805252]

8.   Min Li#, Hui Cai, Ya Yang, Jia Zhang, Kai Sun, Yan Yan, Hangying Qu, Weiwei Wang, Jiansheng Wang*, Xiaoyi Duan*, Perichondrium mesenchymal stem cells inhibit the growth of breast cancer cells via the DKK-1/Wnt/β-catenin signaling pathway, Oncol Rep, 2016 Aug. (SCI, IF= 2.73)[PMID:27277008]

5.   Yan Yan#, Jia Zhang, Junhai Li, Xu Liu, Jizhao Wang, Hangying Qu, Jiansheng Wang*, Xiaoyi Duan*, High tumor-associated macrophages infiltration is associated with poor prognosis and may contribute to the phenomenon of epithelial-mesenchymal transition in gastric cancer, Onco Targets Ther. 2016 Jun 30. (SCI, IF= 2.81)[PMID:27418840]

6.   Kai Sun#, Xiaoyi Duan, Hui Cai, Xiaohong Liu, Ya Yang, Min Li, Xiaoyun Zhang, Jiansheng Wang*, Curcumin inhibits lpa-induced invasion by attenuating rhoa/rock/mmps pathway in mcf7 breast cancer cells, Clin Exp Med. 2016 Feb. (SCI, IF= 2.36)[PMID:25596714]

7.   Jia Zhang#, Jing Zhang, Xiaohai Cui, Ya Yang, Min Li, Jingkun Qu, Junhai Li, Jiansheng Wang*, Foxm1: A novel tumor biomarker of lung cancer, Int J Clin Exp Med. 2015 Mar 15. (SCI, IF= 1.17)[PMID:26064203]

8.   Zhigang Fan#, Xiaoyi Duan, Hui Cai, Li Wang, Min Li, Jingkun Qu, Wanjun Li, YonghengWang, Jiansheng Wang*, Curcumin inhibits the invasion of lung cancer cells by modulating the pkcalpha/nox-2/ros/atf-2/mmp-9 signaling pathway, Oncol Rep. 2015 Aug. (SCI, IF= 2.73)[PMID:26059056]

9.   Jia Zhang#, Min Li#, Ya Yang, Yan Yan, Junhai Li, Jingkun Qu, Jiansheng Wang*, NPR-A: A therapeutic target in inflammation and cancer, Crit Rev Eukaryot Gene Expr, 2015. (SCI, IF= 1.71)[PMID:25955817]

10. Kai Sun#, Hui Cai#, Xiaoyi Duan*, YaYang, Min Li, Jingkun Qu, Xu Zhang, Jiansheng Wang*, Aberrant expression and potential therapeutic target of lysophosphatidic acid receptor 3 in triple-negative breast cancers, Clin Exp Med. 2015 Aug. (SCI, IF= 2.36)[PMID:25209561]

11. Ya Yang#, Min Li, Yan Yan, Jia Zhang, Kai Sun, Jingkun Qu, Jiansheng Wang*, Xiaoyi Duan*, Expression of RAP1B is associated with poor prognosis and promotes an aggressive phenotype in gastric cancer, Oncol Rep. 2015 Nov. (SCI, IF= 2.73)[PMID:26329876]

12. Zhang J, Li M, Yang Y, Jiansheng Wang, et al. NPR-A: A Therapeutic Target in Inflammation and Cancer. Critical Reviews in Eukaryotic Gene Expression, 2015. (SCI, IF= 1.71)[PMID:25955817]

13. Zhang J, Qu J, Wang J. Patch clamp apply in cardiomyocytes derived from patient’s iPS cells for individual anticancer therapy. Int J Clin Exp Med. 2014 Nov 15. (SCI, IF= 1.17)[PMID:25550927]

14. Jia Zhang#, Zhilong Zhao, Jiansheng Wang*, Natriuretic peptide receptor a as a novel target for cancer, World J Surg Oncol. 2014 Jun 3. (SCI, IF= 1.81)[PMID:24894887]

15. Zu C, Wang J. Tumor-colonizing bacteria: a potential tumor targeting therapy. Critical Reviews in Microbiology. Crit Rev Microbiol. 2014 Aug. (SCI, IF= 6.087)[PMID:23964706]

16. Zhao Z, Liu H, Yang Y, Sun K, Li M, Zhang J, Cai H, Wang J. Expression of natriuretic peptide receptor-A in esophageal squamous cell carcinomas and the relationship with tumor invasion and migration. World J Surg Oncol, 2014 May 21. (SCI, IF= 1.2)[PMID:24885858]

17. Jia Z, Zhao Z, Wang J. Natriuretic peptide receptor A as a novel target for cancer. World J Surg Oncol. 2014 Jun 3. (SCI, IF= 1.2)[PMID:24894887]

18. Sun K, Cai H, Duan X, et al. Aberrant expression and potential therapeutic target of lysophosphatidic acid receptor 3 in triple-negative breast cancers. Clin Exp Med. 2015 Aug. (SCI, IF= 2.824)[PMID:25209561]

19. Zhang J, Qu J, Yang Y, et al. Impact of NPR-A expression in gastric cancer cells. Int J Clin Exp Med. 2014 Oct 15. (SCI, IF= 1.422)[PMID:25419351]

20. Shen H ,, Yang Y ,, Xia S ,, et al. Blockage of Nrf2 suppresses the migration and invasion of esophageal squamous cell carcinoma cells in hypoxic microenvironment. Dis Esophagus. 2014 Sep-Oct. (SCI, IF= 2.057)[PMID:24028437]

21. Zhang J, Zhao Z, Chao Z U, et al. Atrial natriuretic peptide modulates the proliferation of human gastric cancer cells via KCNQ1 expression. Oncol Lett. 2013 Aug. (SCI, IF=0.237)[PMID:24137337]

22. Zhao Z, Zhang J, Chen Y, et al. An 11 kg Phyllodes tumor of the breast in combination with other multiple chronic diseases: Case report and review of the literature. Oncol Lett. 2013 Jul. (SCI, IF=0.237)[PMID:23946794]

23. Zhao Z, Zhang J, Li M, et al. ANP-NPRA signaling pathway--a potential therapeutic target for the treatment of malignancy. Crit Rev Eukaryot Gene Expr. 2013. (SCI, IF=2.065)[PMID:23582032]

24. Zhou S, Ye W, Duan X, et al. The noncytotoxic dose of sorafenib sensitizes Bel-7402/5-FU cells to 5-FU by down-regulating 5-FU-induced Nrf2 expression. Dig Dis Sci. 2013 Jun 12. (SCI, IF=2.26)[PMID:23314856]

25. Shen H, Zhou S, Wang J. The paradoxical role of Nrf2 in tumor biology. Crit Rev Eukaryot Gene Expr. 2013. (SCI, IF=2.056)[PMID:23557336]

26. Wang J, Zhang J, Sun J, Han J, Xi Y, Wu G, Duan KX, Zhang M, Zhou S, Liu Q. Prostacyclin administration as a beneficial supplement to the conventional cancer chemotherapy. Med Hypotheses. 2011 Feb 21. [Epub ahead of print] (SCI, IF= 1.393)[PMID: 21345596]

27. Zhou SN, Zhang MX, Wang JS. Tumor-targeted delivery of TAT-Apoptin fusion gene using Escherichia coli Nissle 1917 to colorectal cancer [J]. Med Hypotheses. . 2011 Jan 20. [Epub ahead of print] (Corresponding author, SCI, IF= 1.393)[ PMID: 21256681]

28. Zhang GJ, Gao R, Wang JS, Fu JK, Zhang MX, Jin X. Various doses of fractioned irradiation modulates multidrug resistance 1 expression differently through hypoxia-inducible factor 1α in esophageal cancer cells. Dis Esophagus. 2011 Feb 10. [Epub ahead of print] (Corresponding author, SCI, IF= 1.493)[PMID: 21309917]

29. Ren J, Cai H, Li Y, Zhang X, Liu Z, Wang JS, Hwa YL, Zhang Y, Yang Y, Li Y, Jiang SW. Tumor markers for early detection of ovarian cancer. Expert Rev Mol Diagn. 2010;10(6):787-98. ( SCI, IF= 3.693)

30. Wang JS, Zhang MX, Zhang LM, et al. Correlation of Nrf2, HO-1, and MRP3 in gallbladder cancer and their relationships to clinicopathological features and survival [J]. J Surg Res. 2010, 164(1):e99-105. ( SCI, IF= 2.176)

31. Wang JS, Zhang J, Wu WA, Duan XY, Wang SC, Zhang MX, et al. Studies on gallbladder tissues, tissue plasma membranes and cell lines by FTIR. CHEM J CHINESE U, 2010, 31(3): 484-487. ( SCI, IF= 0.626) (IDS 号: 576WI)

32. Wu WA, Wang JS, Zhang J, Mo F, Wang SC, Zhou SN, Zhang MX, et al. Study on Estimation of Radiation Dose Using FTIR in Mice Thymus. SPECTROSC SPECT ANAL, 2010, 30 (5):1189-1191. ( SCI) (IDS 号: 590VK)

33. Wang J, Zhang J, Wu W, Duan X, Wang S, Zhang M, et al. Evaluation of Gallbladder Lipid Level During Carcinogenesis by an Infrared Spectroscopic Method. Dig Dis Sci, 2010, 55(9):2670-5. ( SCI, IF= 1.838) (IDS 号: 634PN)

34. Xiaojiang T, Jinsong Z, Jiansheng W, et al. Adeno-Associated Virus Harboring Fusion Gene NT4-Ant-Shepherdin Induce Cell Death in Human Lung Cancer Cells [J]. Cancer Invest. 2010;28(5):465-71. (SCI, IF= 2.105) (IDS 号: 610NL)

35. Zhang W, He J, Wang J, Bai H, Zhang X, Zhang G, Ren Y, Wang K, Xu J, Niu L, Zhou Y, Chen W. Ulcerated epithelioid hemangioendothelioma of the right armpit in childhood. Pediatr Hematol Oncol. 2009; 31(8):595-8. (SCI, IF= 1.032) (IDS 号: 481MH)

36. Duan X, Han D, Zhang M, Wang JS. Generation of fusion protein EGFRvIII-HBcAg and its anti-tumor effect in vivo [J]. J Exp Clin Cancer Res. 2009, 28:133. (SCI, IF= 1.287) (IDS 号: 508KX)

37. Du JK, Shi JS, Sun XJ, Wang JS, et al. Fourier transform infrared spectroscopy of gallbladder carcinoma cell line. Hepatobiliary Pancreat Dis Int, 2009, 8:75-8. (SCI, IF= 1.183) (IDS 号: 409EI)

38. Duan XY, Wang JS, Zhang MX, et al. Generation of fusion protein EGFRvIII-HBcAg and its anti-tumor effect in vivo [J]. Ann Oncol, 2009, 20:34-34. (SCI, IF=4.935) (IDS 号: 451VD)

39. Du JK, Shi JS, Xu YZ, Zhang YF, Sun XJ, Wang JS, et al. FTIR spectroscopic study on carcinoma cells [J]. Guang Pu Xue Yu Guang Pu Fen Xi, 2008, 28:51-54. (SCI) (IDS 号: 257PB)

40. Duan XY, Wang JS, Liu M, Guo YM. Technetium-99m-hexakis-2- methoxyisobutylisonitrile scintigraphy and multidrug resistance-related protein expression in human primary lung cancer [J]. Ann Nucl Med, 2008, 22:49-55. (SCI, IF= 0.917) (IDS 号: 259DB)

41. Jiansheng W, Mingxing Z, Xiaoyi D, et al. Construction of secretory eukaryotic expression vector of NT4-APOPTIN-HA2-TAT and its effects on tumor cells [J]. Mol Cancer Ther, 2007, 6:3618S-3618S. (SCI, IF= 5.003)( IDS 号: 034WQ)

42. Li X, Li QB, Xu YZ, Zhang GJ, Wu JG, Yang LM, Ling XF, Zhou XS, Wang JS. Application of KNN method to cancer diagnosis using Fourier-transform infrared spectroscopy. Guang Pu Xue Yu Guang Pu Fen Xi, 2007, 27:439-43. (SCI) ( IDS 号: 154FK)

43. Li QB, Li X, Xu YZ, Soloway RD, Ling XF, Wang JS, Zhang GJ, Zhou XS, Shi JS, Wang BB, Pan QH, Wu JG. Gastroenterology, 2006, 130(4) Suppl. 2: A473-A473. (SCI) (IDS 号: 034WQ)

44. Shi JS, Soloway RD, Li QB, Sun XJ, Wang JS, Xu YZ, Weng SF, Liu Z, Wang F, Yang LM, Xu DF, Wu JG. Identification of cancer in lymph nodes using Fourier transform infrared (FT-IR) attenuated total reflectance (ATR) spectroscopy. Comparison with pathology. Gastroenterology, 2004, 126(4 Suppl. 2):A199-A199. (SCI) (IDS 号: 813EK)

45. Yang J, Ren Y, Xu YZ, Su YL, Zhang L, Liu Z, Wang F, Yang LM, Wang J, Gao HC, Ye F, Wu JG. Interaction between DNA and terbium(III)-ciprofloxacin fluorescence complex and new tissue staining method. CHEM J CHINESE U, 2004, 25(2):243-246. (SCI) (IDS 号: 777PU)

46. Griffiths PR, Yang HS, Li QB, Ling XF, Wang JS, et al. Discrimination of normal and malignant gastric tissues with FTIR spectroscopy and principal component analysis [J]. Guang Pu Xue Yu Guang Pu Fen Xi, 2004,24:1025-7. (SCI) (IDS 号: 927WH)

47. Li QB, Yang LM, Ling XF, Wang JS, et al. Application of the SIMCA method to cancer diagnosis with Fourier-transform infrared spectroscopy. Guang Pu Xue Yu Guang Pu Fen Xi, 2004, 24:414-7. (SCI) (IDS 号: 154FK)

48. Wang JS, Shi JS, Xu YZ, et al. FT-IR spectroscopic analysis of normal and cancerous tissues of esophagus [J]. World J Gastroenterol, 2003, 9:1897-9. (SCI) (IDS 号: 726CD)

49. Zhang L, Wang JS, Yang ZL, et al. The difference of FTIR spectroscopic studies on normal and malignant tissues of lung [J]. Chemical Journal of Chinese Universities, 2003, 24: 2173- 2176. (SCI) (IDS 号: 777PU)

50. Ren Y, Xu YZ, Wang JS, et al. FTIR spectroscopic and statistical studies on the lung tissues [J]. Guang Pu Xue Yu Guang Pu Fen Xi, 2003, 23: 681-684. (SCI) (IDS 号: 717KK)

51. Wang JS, Xu YZ, Shi JS, et al. FTIR spectroscopic study on normal and cancerous tissues of esophagus [J]. Guang Pu Xue Yu Guang Pu Fen Xi, 2003, 23: 863-865. (SCI) (IDS 号: 739ZJ)

52. Ma J, Wang JS, Soloway RD, et al. Separation of normal from diseased hepatocytes using Fourier transform infrared (FT-IR) spectroscopy: A basis for histologic characterization and quantitation [J]. Gastroenterology, 2002, 122: A306-A307. (SCI) (IDS 号: 548AW)

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更新日期:2019-05-07